02/11/2015
Mg++: Médicament de la coagulopathie ?
Both acute delivery of and storage with magnesium sulfate promote cold-stored platelet aggregation and coagulation function
Meledeo MA et Al. J Trauma Acute Care Surg. 2015 Oct;79(4 Suppl 2):S139-45
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Il y a quelque mois était publié un travail de recherche portant sur l'intérêt de l'administration de Adénosine/Lidocaïne/Mg2+ ALM (1, 2, 3). Une hypothèse faite par les auteurs serait que L'ALM agirait comme un antifibrinolytique en activant la voie du thrombin-activatable fibrinolysis inhibitor (TAFI) plutôt que celle de la protéine C. Cette action passerait par un mécanisme antiinflammatoire, une modification de la polarité endothéliale et une action sur la fonction plaquettaire. Le travail expérimental dont l'abstract est présenté met en avant l'intérêt de l'adminsitration de magnésium pour la restauration de la fonction plaquettaire après conservation de palquettes d'aphérèse au delà de 5 jours.
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BACKGROUND:
The platelet storage lesion causes loss of function and viability over time. A new paradigm for platelet storage is desired to enable safer, more effective transfusions while reducing waste. We hypothesized that repletion of Mg, which is chelated by citrate anticoagulant, could reduce platelet storage lesion severity when given in conjunction with storage at a refrigerated temperature.
METHODS:
Apheresis platelet units were collected from healthy donors and stored at 22°C or 4°C. On Days 0, 2, 4, and 8, samples were collected for analyses of receptor-mediated aggregation, coagulation, adhesion to collagen under flow, and viability. In the first series, samples were given anacute dose of MgSO4 before testing; in the second series, storage bags were supplemented with 0-, 3-, or 6-mM MgSO4.
RESULTS:
Acutely delivered MgSO4 induced a more rapid coagulation time in apheresis platelets, further enhanced by storage at 4°C. Plateletadhesion to a collagen surface while exposed to arterial shear rates (920 s) was enhanced by MgSO4 supplementation-acute MgSO4 had a large effect on adhesion of fresh platelets, which diminished more rapidly in 22°C samples, while storage with MgSO4 showed significant benefits even out to Day 4 at both temperatures. Although 4°C storage improves the longevity of platelet aggregation responses to agonists, MgSO4 supplementation did not change those responses.
CONCLUSION:
Acute MgSO4 reduces clot time likely through the transient increase of free Ca. Limited differences between platelet function inacute delivery of and storage with MgSO4 diminish the possibility that Mg-induced metabolic inhibition of platelets synergizes with 4°C storage. Regardless, magnesium supplementation to platelets is an exciting possibility in transfusion because the adhesion response of 22°C-stored platelets on Day 4 is significantly enhanced when stored with 6-mM MgSO4
| Tags : coagulopathie
01/11/2015
IED à pied: Amputations 2aires fréquentes
Outcomes after Long-Term Follow-Up of Combat-Related Extremity Injuries in a Multidisciplinary Limb Salvage Clinic
Casey K et Al. Ann Vasc Surg. 2015 Apr;29(3):496-501
Background: Although the incidence of casualties from the Global War on Terror is decreasing, there remains a focus on the long-term sequelae from injuries sustained in the combat. Patients with prior significant limb injuries remain at risk of future complications. This study examines our institution’s experience with a multidisciplinary team approach toward this challenging patient population.
Methods: A retrospective review was performed on all patients treated in a single institution Limb Preservation Clinic over a 2-year period. Those patients who sustained a combatrelated injury in theater were examined. Patient demographics, mechanism of injury, amputation rates, time to amputation, and reasons for failure were examined.
Results: Ninety-four patients were evaluated in our multidisciplinary Limb Preservation Clinic over a 2-year period. Twenty patients (21%) were seen for combat-related injuries. Sixteen patients were evaluated and treated for chronic complications at a median of 13 months from their injury. All 16 patients were male with a median age of 24 years (range, 20e35). Ten patients sustained injuries secondary to a dismounted improvised explosive device (IED). All 16 patients had extensive soft tissue injuries and associated fractures. Only 2 patients sustained a vascular injury. The median number of prior surgeries to the affected limb was 8 (range, 3e19). The limb salvage rate of 37% was lower than our noncombat cohort (47%). The most common reasons for delayed amputation included chronic pain, osteomyelitis, and soft tissue infections.
Conclusions: The high secondary amputation rates seen in this cohort underscores the need for long-term follow-up. Despite successful initial outcomes, many patients eventually progress to limb loss. Patients who sustain a dismounted IED are at greatest risk for a delayed amputation. Identifying and addressing those factors which lead to delayed amputation should be a priority for returning war veterans and focus of future studies.
23/10/2015
Quelle place pour les facteurs de la coagulation ?
Clic sur l'image pour suivre la conférence
| Tags : hémorragie, coagulopathie, choc
11/10/2015
Les blessés français en afghanistan
09/10/2015
Pas bon si TA < 100
Hypotension is 100 mm Hg on the battlefield
Eastridge DJ et All. Am J Surg. 2011 Oct;202(4):404-8
BACKGROUND:
Historically, emergency physicians and trauma surgeons have referred to a systolic blood pressure (SBP) of 90 mm Hg as hypotension. Recent evidence from the civilian trauma literature suggests that 110 mm Hg may be more appropriate based on associated acidosis and outcome measures. In this analysis, we sought to determine the relationship between SBP, hypoperfusion, and mortality in the combat casualty.
METHODS:
A total of 7,180 US military combat casualties from the Joint Theater Trauma Registry from 2002 to 2009 were analyzed with respect to admission SBP, base deficit, and mortality. Base deficit, as a measure of hypoperfusion, and mortality were plotted against 10-mm Hg increments in admission SBP.
RESULTS:
By plotting SBP, baseline mortality was less than 2% down to a level of 101 to 110 mm Hg, at which point the slope of the curve increased dramatically to a mortality rate of 45.1% in casualties with an SBP of 60 mm Hg or less but more than 0 mm Hg. A presenting SBP of 0 mm Hg was associated with 100% mortality. The data also established a similar effect for base deficit with a sharp increase in the rate of acidosis, which became manifest at an SBP in the range of 90 to 100 mm Hg.
CONCLUSIONS:
This analysis shows that an SBP of 100 mm Hg or less may be a better and more clinically relevant definition of hypotension and impending hypoperfusion in the combat casualty. One utility of this analysis may be the more expeditious identification of battlefield casualties in need of life-saving interventions such as the need for blood or surgical intervention.
20/09/2015
The Operational Patient Care Pathway
The Operational Patient Care Pathway
Une évolution importante de nos amis anglais qui précise le concept du "Prolonged Field Care" et révisent le concept de la golden Hour et des minutes de platine pour le 10-1-2 + 2
For debate: the Operational Patient Care Pathway
Bricknell M. J R Army Med Corps. 2014 Mar;160(1):64-9
| Tags : tactique
18/09/2015
Coagulopathie traumatique: Mécanismes
Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research
Gonzales E. et Al. Scandinavian Journal of Surgery 103: 89–103, 2014
| Tags : coagulopathie
01/08/2015
Milieu isolé: Mieux vaut avoir été préparé(e)
Preparing for Operations in a Resource-Depleted and/or Extended Evacuation Environment
Corey G et Al. J Spec Oper Med. 2013 Fall;13(3):74-80
The wars in Afghanistan and Iraq are the only conflicts to which many medics have ever been exposed. These mature theaters have robust medical systems that ensure rapid access to full-spectrum medical care for all combat-wounded and medically injured personnel. As current conflicts draw to a close, U.S. medics may be deployed to environments that will require the ability to stabilize casualties for longer than 1 hour. Historical mission analysis reveals the need to review skills that have not been emphasized during upgrade and predeployment training. This unit’s preparation for the extended care environment can be accomplished using a 4-point approach: (1) review of specific long-term skills training, (2) an extended care lab that reviews extended care skills and then lets the medic practice in a real-time scenario, (3) introduction to the HITMAN mnemonic tool, which helps identify and address patient needs, and (4) teleconsultation.
30/07/2015
ATLS: Référence en ballistique ? Bof !
Myths and Misinformation About Gunshot Wounds may Adversely Affect Proper Treatment.
Hafertepen SC et Al. World J Surg. 2015 Jul;39(7):1840-7
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La pertinence de l'ATLS est régulièrement battue en brèche pour les systèmes de prise en charge des traumatisés organisés en réseau. Historiquement il s'agissait d'apporter des connaissances de base à des équipes novices en la matière. Une revue cochrane n'est pas du tout en faveur. Un éditorial récent, mais il n'est pas isolé, exprime bien le caractère non adapté de ce concept à la réalité des trauma center actuels. Certains vont très loin dans la critique mettant en évidence dans le contenu même des dernières révisions la retranscription de données non validées. C'est le cas du document proposé. Au delà du caractère structurant réel d'un acronyme, c'est bien d'un contenu basique (trop) et souvent erroné dont nous devons être conscient.
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BACKGROUND:
Poorly designed experiments and popular media have led to multiple myths about wound ballistics. Some of these myths have been incorporated into the trauma literature as fact and are included in Advanced Trauma Life Support (ATLS). We hypothesized that these erroneous beliefs would be prevalent, even among those providing care for patients with gunshot wounds (GSWs), but could be addressed through education.
METHODS:
ATLS course content was reviewed. Several myths involving wound ballistics were identified. Clinically relevant myths were chosen including wounding mechanism, lead poisoning, debridement, and antibiotic use. Subsequently, surgery and emergency medicine services at three different trauma centers were studied. All three sites were busy, urban trauma centers with a significant amount of penetrating trauma. A pre-test was administered prior to a lecture on wound ballistics followed by a post-test. Pre- and post-test scores were compared and correlated with demographic data including ATLS course completion, firearm/ballistics experience, and years of post-graduate medical experience (PGME).
RESULTS:
One-hundred and fifteen clinicians participated in the study. A mean pre-test score of 34 % improved to 78 % on the post-test with associated improvements in all areas of knowledge (p < 0.001). Years of PGME correlated with higher pre-test score (p = 0.021); however, ATLSstatus did not (p = 0.774).
CONCLUSIONS:
Erroneous beliefs involving wound ballistics are prevalent even among clinicians who frequently treat victims of GSWs and could lead to inappropriate treatment. Focused education markedly improved knowledge. The ATLS course and manual promulgate some of these myths and should be revised.
20/07/2015
Echo en hélico: Avec formation solide !
Prospective evaluation of prehospital trauma ultrasound during aeromedical transport.
Press GM et Al. J Emerg Med. 2014 Dec;47(6):638-45
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L'apport de l'échographie est incontournable pour la prise en charge des traumatisés. Son emploi en prehospitalier est proposé. Pour autant la mise en oeuvre de ce moyen d'exploration n'est pas si simple et demande une grande expertise. Le travail présenté porte sur la mise en oeuvre de ce type d'exploration par technicinens paramédicaux expérimentés et ayant suivi une formation sur une période de deux mois. malgré cela leur performance reste modeste. Un examen négatif de permet pas de conclure. Ceci plaide pour un peu de modération concernant l'engouement actuel. Comme pour tout il faut investir sur la formation pour être performant.
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BACKGROUND:
Ultrasound is widely considered the initial diagnostic imaging modality for trauma. Preliminary studies have explored the use of trauma ultrasound in the prehospital setting, but the accuracy and potential utility is not well understood.
OBJECTIVE:
We sought to determine the accuracy of trauma ultrasound performed by helicopter emergency medical service (HEMS) providers.
METHODS:
Trauma ultrasound was performed in flight on adult patients during a 7-month period. Accuracy of the abdominal, cardiac, and lung components was determined by comparison to the presence of injury, primarily determined by computed tomography, and to required interventions.
RESULTS:
HEMS providers performed ultrasound on 293 patients during a 7-month period, completing 211 full extended Focused Assessment with Sonography for Trauma (EFAST) studies. HEMS providers interpreted 11% of studies as indeterminate. Sensitivity and specificity for hemoperitoneum was 46% (95% confidence interval [CI] 27.1%-94.1%) and 94.1% (95% CI 89.2%-97%), and for laparotomy 64.7% (95% CI 38.6%-84.7%) and 94% (95% CI 89.2%-96.8%), respectively. Sensitivity and specificity for pneumothorax were 18.7% (95% CI 8.9%-33.9%) and 99.5% (95% CI 98.2%-99.9%), and for thoracostomy were 50% (95% CI 22.3%-58.7%) and 99.8% (98.6%-100%), respectively. The positive likelihood ratio for laparotomy was 10.7 (95% CI 5.5-21) and for thoracostomy 235 (95% CI 31-1758), and the negative likelihood ratios were 0.4 (95% CI 0.2-0.7) and 0.5 (95% CI 0.3-0.8), respectively. Of 240 cardiac studies, there was one false-positive and three false-negative interpretations (none requiring intervention).
CONCLUSIONS:
HEMS providers performed EFAST with moderate accuracy. Specificity was high and positive interpretations raised the probability of injury requiring intervention. Negative interpretations were predictive, but sensitivity was not sufficient for ruling out injury.
| Tags : échographie
Dossier sauvetage au combat
Dossier "Sauvetage au combat"
01 Pierret C. Les traumatismes jonctionnels en situation de guerre.Medecine et Armees 2014-4.291-9.(format pdf, 175 kB).
02 Precloux P. Operation Pamir bilan et analyse activite des postes medicaux role 1 RSA 2011. Medecine et Armees 2014-4. 299-309.(format pdf, 315 kB).
03 Leyral J. Echographie de l avant au Role 1 quelle formation pour medecin unite.Medecine et Armees 2014-4.309-14.(format pdf, 98 kB).
04 Favier LC.Quelles devraient etre les indications de l echographie en Role 1. Medecine et Armees 2014-4.315-20.(format pdf, 140 kB).
05. Danguy M. Actualisation des garrots de type tourniquet. Medecine et Armees 2014-4. 321-8.(format pdf, 149 kB).
06. Mathieu L. Délabrements etendus par blast a haute intensite.nouvelle entite lesionnelle EEI. Medecine et Armees 2014-4. 329-5.(format pdf, 198 kB).
07 Mathieu L. Traumatismes par blast de arriere pied lies aux attaques de vehicules par EEI. Medecine et Armees 2014-4.337-44.(format pdf, 273 kB).
08 Gunepin M. Evacuations medicales intra-theatres pour raisons dentaires au cours operation Serval. Medecine et Armees 2014-4.345-51.(format pdf, 126 kB).
09 Crehange G. Etude de la qualite de l air a Kaboul. Medecine et Armees 2014-4.353-61.(format pdf, 113 kB).
| Tags : sauvetage
11/07/2015
ATLS: Une vision archaïque ?
ATLS: Archaic Trauma Life Support?
Wiles MD Anaesthesia 2015, 70, 893–906
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Un éditorial décoifffant mais pas tant que cela. Une revue cochrane récente ne trouvait pas d'argument en faveur de l'intérêt de l'ATLS (1). Le bien fondé de ce type de fromation est très débattue dans les pays disposant d'une structure spécialisée de prise en charge de traumatisé( 2). Peu étonnant quand on connait l'histoire de l'ATLS censé apporter des connaissances et une méthode à des personnels et des structures hospitalières non spécialisées en traumatologie. Les conclusions de cet éditorial repositionne très bien ce type de formations courtes
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No one could have imagined that when a light aircraft crashed in rural Nebraska in 1976, the nature of global trauma management would be forever altered. James Styner, an orthopaedic surgeon, was piloting the plane in question and the accident resulted in the death of his wife and serious injuries to himself and his four children. The standard of care that he and his family received in the local hospital in the aftermath of the crash so horrified Styner that he decided to establish a new system for the management of major trauma...........................
......So what direction should trauma training take in the future?
I would suggest the following:
1 Treat ATLS as a ‘basic’ trauma course, with attendance limited to junior medical staff with no trauma experience. Candidates will learn the common language and vocabulary of trauma management, which will be of benefit when they subsequently attend trauma calls in clinical practice. In the developing world, where resources and personnel are limited, ATLS will continue to have a role.
2 Stop routine recertification of ATLS for individuals experienced in trauma management. Given the high cost of these courses (~£600 (€825; $918) for certification and £350 (€482; $535) for recertification) this practice will account for a significant proportion of an individual’s annual study leave budget. This time and money would be better invested in developing enhanced leadership, communication and teamworking skills.
3 In line with the Royal College of Anaesthetists, remove ATLS certification as a prerequisite for the completion of training in surgery and emergency medicine. Instead, focus on ensuring adequate experience in the management of major trauma.
4 Similarly, for consultant posts that include trauma management, remove ATLS certification as an appointment criterion.
Evidence of experience in trauma management, alongside formal training in leadership and/or human factors, would be of greater relevance.
5 Require regular team-training sessions for MTC staff, either by video review or utilising simulation, ideally within the team’s usual working environment. This would allow training to be institution-specific, with the potential to refine protocols and undertake focused debriefs of recent cases.
When introduced almost 40 years ago, ATLS represented the cutting edge of trauma management; unfortunately, the course has failed to evolve at a pace that allows it to be relevant to the care delivered in modern MTCs. This course without doubt revolutionised trauma care, but it should now be reserved for use in isolated rural centres or environments where trauma is managed infrequently and with limited resources. The King is dead, long live the King.
03/07/2015
Fibrinogène avec le TXA ?: Plutôt oui
Association of Cryoprecipitate and Tranexamic Acid With Improved Survival Following Wartime Injury: Findings From the MATTERs II Study
Morrison JJ et Al. JAMA Surg. 2013;148(3):218-225.
Objective To quantify the impact of fibrinogen-containing cryoprecipitate in addition to the antifibrinolytic tranexamic acid on survival in combat injured.
Design Retrospective observational study comparing the mortality of 4 groups: tranexamic acid only, cryoprecipitate only, tranexamic acid and cryoprecipitate, and neither tranexamic acid nor cryoprecipitate. To balance comparisons, propensity scores were developed and added as covariates to logistic regression models predicting mortality.
Setting A Role 3 Combat Surgical Hospital in southern Afghanistan.
Patients A total of 1332 patients were identified from prospectively collected UK and US trauma registries who required 1 U or more of packed red blood cells and composed the following groups: tranexamic acid (n = 148), cryoprecipitate (n = 168), tranexamic acid/cryoprecipitate (n = 258), and no tranexamic acid/cryoprecipitate (n = 758).
Main Outcome Measure In-hospital mortality.
Results Injury Severity Scores were highest in the cryoprecipitate (mean [SD], 28.3 [15.7]) and tranexamic acid/cryoprecipitate (mean [SD], 26 [14.9]) groups compared with the tranexamic acid (mean [SD], 23.0 [19.2]) and no tranexamic acid/cryoprecipitate (mean [SD], 21.2 [18.5]) (P < .001) groups. Despite greater Injury Severity Scores and packed red blood cell requirements, mortality was lowest in the tranexamic acid/cryoprecipitate (11.6%) and tranexamic acid (18.2%) groups compared with the cryoprecipitate (21.4%) and no tranexamic acid/cryoprecipitate (23.6%) groups. Tranexamic acid and cryoprecipitate were independently associated with a similarly reduced mortality (odds ratio, 0.61; 95% CI, 0.42-0.89; P = .01 and odds ratio, 0.61; 95% CI, 0.40-0.94; P = .02, respectively). The combined tranexamic acid and cryoprecipitate effect vs neither in a synergy model had an odds ratio of 0.34 (95% CI, 0.20-0.58; P < .001), reflecting nonsignificant interaction (P = .21).
Conclusions Cryoprecipitate may independently add to the survival benefit of tranexamic acid in the seriously injured requiring transfusion. Additional study is necessary to define the role of fibrinogen in resuscitation from hemorrhagic shock.
| Tags : coagulopathie
21/06/2015
Military Trauma System: Pour le civil ?
Military trauma system in Afghanistan: lessons for civil systems?
Bailey JA et Al. Curr Opin Crit Care. 2013 Dec;19(6):569-77
PURPOSE OF REVIEW:
This review focuses on development and maturation of the tactical evacuation and en route care capabilities of the military trauma system in Afghanistan and discusses hard-learned lessons that may have enduring relevance to civilian trauma systems.
RECENT FINDINGS:
Implementation of an evidence-based, data-driven performance improvement programme in the tactical evacuation and en route care elements of the military trauma system in Afghanistan has delivered measured improvements in casualty care outcomes.
SUMMARY:
Transfer of the lessons learned in the military trauma system operating in Afghanistan to civilian trauma systems with a comparable burden of prolonged evacuation times may be realized in improved patient outcomes in these systems.
Un nouveau concept de triage ?
Medical evacuation and triage of combat casualties in Helmand Province, Afghanistan: October 2010-April 2011
Clarke JE et Al. Mil Med. 2012 Nov;177(11):1261-6
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Un article de synthèse sur l'organisation de la chaîne de prise en charge des blessés par nos confrères anglais, avec notamment l'emploi d'une évolution majeure pour le un système anglo-saxon (lire ce document): le recours à des EVASAN médicalisées par des personnels ayant une pratique régulière de la prise en charge de patients en état critique. Cet article est intéressant car il insiste sur l'importance du triage et le rôe prééminent que peuvent jouer les role 2 notamment si les élongations sont importantes.
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Medical evacuation of combat casualties in Operation Enduring Freedom-Afghanistan is achieved primarily by helicopter, because of distances involved as well as ground-based threats. In Helmand Province, evacuation from the point of injury may occur on a variety of helicopter evacuation platforms with disparate levels of attendant medical expertise. Furthermore, triage to a medical treatment facility may involve varying echelons of care before definitive management. Consequently, considerable differences in medical care may be encountered between point of injury and definitive treatment. We discuss the role of helicopter-based medical evacuation in Helmand, Afghanistan, as well as triage and timelines to the most appropriate medical facilities. Based on our experience and available evidence, we have made recommendations to regional commanders which favor the utilization of prehospital critical care teams aboard helicopter-based evacuation platforms and direct triage to the highest echelon of care available when feasible
06/06/2015
Prise en charge d'un blessé: Ce n'est pas le SAMU, ni la catastrophe
Tactical medicine: a joint forces field algorithm.
Waldman M et Al. Mil Med. 2014 Oct;179(10):1056-61
20/03/2015
Guidelines for field management of combat related head trauma
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07/03/2015
Mise en place du TCCC: Le point 2014
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| Tags : tccc
06/03/2015
Mise en place du TCCC: Le point 2013
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| Tags : tccc
27/02/2015
Plaies par armes blanches
Elles ne sont pas très fréquentes dans notre contexte, le plus souvent accidentelles ou secondaires à des rixes entre villageois.
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