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19/12/2015

Military medicine in the 21st

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Amputé des jambes: Le bassin aussi !

The incidence of pelvic fractures with traumatic lower limb amputation in modern warfare due to improvised explosive devices

Cross AM et Al. J R Nav Med Serv 2014;100(2):152-6

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Excepté l'extraction d'urgence de blessés sous le feu, la prise en charge den cas d'amputation traumatique doit inclure la forte probabilité de traumatisme du bassin. Une utilisation large des immobilisations pelviennes doit donc être à l'esprit. On rappelle simplement la gravité et la difficulté de prise en charge des hémorragies liées aux fractures de bassin.

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AIMS:

A frequently-seen injury pattern in current military experience is traumatic lower limb amputation as a result of improvised explosive devices (IEDs). This injury can coexist with fractures involving the pelvic ring. This study aims to assess the frequency of concomitant pelvic fracture in IED-related lower limb amputation.

METHODS:

A retrospective analysis of the trauma charts, medical notes, and digital imaging was undertaken for all patients arriving at the Emergency Department at the UK military field hospital in Camp Bastion, Afghanistan, with a traumatic lower limb amputation in the six months between September 2009 and April 2010, in order to determine the incidence of associated pelvic ring fractures.

RESULTS:

Of 77 consecutive patients with traumatic lower limb amputations, 17 (22%) had an associated pelvic fracture (eleven with displaced pelvic ring fractures, five undisplaced fractures and one acetabular fracture). Unilateral amputees (n = 31) had a 10% incidence of associated pelvic fracture, whilst 30 % of bilateral amputees (n = 46) had a concurrent pelvic fracture. However, in bilateral, trans-femoral amputations (n = 28) the incidence of pelvic fracture was 39%.

PelvicFractures.jpg

BKA - Below knee amputation; AKA - Above knee amputation

CONCLUSIONS:

The study demonstrates a high incidence of pelvic fractures in patients with traumatic lower limb amputations, supporting the routine pre-hospital application of pelvic binders in this patient group

PelvicImmobilisation.jpg

17/12/2015

Médicaliser: Pour faire quoi ?

Doctor on board ? What is the optimal skill-mix in military pre-hospital care ?

Calderbank P. et Al.  Emerg Med J (2010). doi:10.1136/emj.2010.097642

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Le document proposé à la lecture porte sur l'intérêt de la présence d'un médecin dans la plus avancée des structures medevac qui existe actuellement: Les MERT-E des anglais. Seule 1 medevac sur 5 justifiait la présence d'un médecin. L'intervention la plus fréquemment réalisée a été l'intubation/induction en séquence rapide. Bien loin devant d'autres gestes comme la thoracostomie ou le drainage thoracique. Ceci étant dit ce constat est fait dans un contexte spécifique afghan qui ne correspond pas aux opérations actuelles où les délais de prise en charge chirurgicales peuvent être long. Cette pratique est donc essentielle à maîtriser et procède d'une véritable stratégie de formation, avec une rythmicité semestrielle,  débutée dès la formation initiale, associant un parcours structuré de mises à jour technique personnelle (passage en bloc opératoire, participation à des ateliers sur simulateurs de taches) et collective. Il s'agit d'un exemple parmi d'autres où une implication personnelle forte doit être présente.

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Background

In a military setting, pre-hospital times may be extended due to geographical or operational issues. Helicopter casevac enables patients to be transported expediently across all terrains. The skill-mix of the prehospital team can vary. Aim To quantify the doctors’ contribution to the Medical Emergency Response TeameEnhanced (MERT-E).

Methods

A prospective log of missions recorded urgency category, patient nationality, mechanism of injury, medical interventions and whether, in the crew’s opinion, the presence of the doctor made a positive contribution.

Results

Between July and November 2008, MERT-E flew 324 missions for 429 patients. 56% of patients carried were local nationals, 35% were UK forces. 22% of patients were T1, 52% were T2, 21.5% were T3 and 4% were dead. 48% patients had blast injuries, 25% had gunshot wounds, 6 patients had been exposed to blast and gunshot wounds. Median time from take-off to ED arrival was 44 min. A doctor flew on 88% of missions. It was thought that a doctor’s presence was not clinically beneficial in 77% of missions. There were 62 recorded physician’s interventions: the most common intervention was rapid sequence induction (45%); other interventions included provision of analgesia, sedation or blood products (34%), chest drain or thoracostomy (5%), and pronouncing life extinct (6%).

Conclusion

MERT-E is a high value asset which makes an important contribution to patient care. A relatively small proportion of missions require interventions beyond the capability of well-trained military paramedics; the indirect benefits of a physician are more difficult to quantify.

| Tags : airway

13/11/2015

Demain: Quels enjeux ?

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09/11/2015

Plaie cérébrale et coagulopathie

Quelques faits

1. Elle est fréquente voire très fréquente: Greuters et al. Critical Care 2011 15:R2   doi:10.1186/cc9399

 

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2. Elle est + fréquente en cas d'hypoTA: Wafaisade  Neurocrit Care. 2010 Apr;12(2):211-9

COT TBI.jpg

3. Elle est de mauvais pronostic: J Emerg Trauma Shock. 2013 Jul-Sep; 6(3): 180–185

JETS-6-180-g002.jpg

4. Elle est mise en évidence plutôt par thromboélastographie (r TEG) : Sixta al., J Neurol Neurophysiol 2014, 6:5

rTEG TBI Coagulopathy.jpg

Un point plus complet

| Tags : coagulopathie

08/11/2015

Damage Control: Vraiment bénéfique

Changing Patterns of In-Hospital Deaths Following Implementation of Damage Control Resuscitation Practices in US Forward Military Treatment Facilities

Langan NR et Al. JAMA Surg. 2014;149(9):904-912

Importance

Analysis of combat deaths provides invaluable epidemiologic and quality-improvement data for trauma centers and is particularly important under rapidly evolving battlefield conditions.

Objective

To analyze the evolution of injury patterns, early care, and resuscitation among patients who subsequently died in the hospital, before and after implementation of damage control resuscitation (DCR) policies.

Design, Setting, and participants

In a review of the Joint Theater Trauma Registry (2002-2011) of US forward combat hospitals, cohorts of patients with vital signs at presentation and subsequent in-hospital death were grouped into 2 time periods: pre-DCR (before 2006) and DCR (2006-2011).

Main outcomes and measures

Injury types and Injury Severity Scores (ISSs), timing and location of death, and initial (24-hour) and total volume of blood products and fluid administered.

Results 

Of 57 179 soldiers admitted to a forward combat hospital, 2565 (4.5%) subsequently died in the hospital. The majority of patients (74%) were severely injured (ISS > 15), and 80% died within 24 hours of admission. Damage control resuscitation policies were widely implemented by 2006 and resulted in a decrease in mean 24-hour crystalloid infusion volume (6.1-3.2 L) and increased fresh frozen plasma use (3.2-10.1 U) (both P < .05) in this population. The mean packed red blood cells to fresh frozen plasma ratio changed from 2.6:1 during the pre-DCR period to 1.4:1 during the DCR period (P < .01). There was a significant increase in mean ISS between cohorts (pre-DCR ISS = 23 vs DCR ISS = 27; P < .05) and a marked shift in injury patterns favoring more severe head trauma in the DCR cohort.

DCR BeforeAfter.jpg

Conclusions and relevance

There has been a significant shift in resuscitation practices in forward combat hospitals indicating widespread military adoption of DCR. Patients who died in a hospital during the DCR period were more likely to be severely injured and have a severe brain injury, consistent with a decrease in deaths among potentially salvageable patients

 

 

| Tags : remplissage

06/11/2015

Prolonged field Care: Novateur ? Pas vraiment

Prolonged Field Care Working Group Position Paper Prolonged Field Care Capabilities

Bal JA et All. J Spec Oper Med. 2015 Fall;15(3):78-80

Le concept du TCCC, issu de l'analyse des décès au combat lors de la guerre de Somalie, a vu toute sa pertinence prouvée en afghanistan. Des gestes simples réalisés par des soldats et des combat medic ont permis d'éviter le décès de nombre de soldats. Ces derniers étaient alors évacués rapidement vers des structures chirurgicales. Le concept afghan permettait cela.

PFC.jpg

Ce n'est pas le cas des conflits actuels, conflits pendant lesquels le combattant blessé doit se voir appliquer pendant plusieurs heures une démarche de prise en charge (remplissage, analgésie, nursing,..) très proche de la réanimation préhospitalière. C'est bien compte tenu de l'absence de médecins et donc de connaissances en la matière que cette pratique de prise en charge est considérée par nos collègues US comme nouvelle. Ce concept ne doit donc pas probablement être considéré comme novateur pour nous car il s'agit d'une démarche de convergence d'une pratique anglo-saxonne vers notre médicalisation de l'avant. 

02/11/2015

Mg++: Médicament de la coagulopathie ?

Both acute delivery of and storage with magnesium sulfate promote cold-stored platelet aggregation and coagulation function

Meledeo MA et Al. J Trauma Acute Care Surg. 2015 Oct;79(4 Suppl 2):S139-45

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Il y a quelque mois était publié un travail de recherche portant sur  l'intérêt de l'administration de Adénosine/Lidocaïne/Mg2+ ALM (1, 2, 3). Une hypothèse faite par les auteurs  serait que L'ALM agirait comme un antifibrinolytique en activant la voie du thrombin-activatable fibrinolysis inhibitor (TAFI) plutôt que celle de la protéine C. Cette action passerait par un mécanisme antiinflammatoire, une modification de la polarité endothéliale et une action sur la fonction plaquettaire. Le travail expérimental dont l'abstract est présenté met en avant l'intérêt de l'adminsitration de magnésium pour la restauration de la fonction plaquettaire après conservation de palquettes d'aphérèse au delà de 5 jours. U

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BACKGROUND:

The platelet storage lesion causes loss of function and viability over time. A new paradigm for platelet storage is desired to enable safer, more effective transfusions while reducing waste. We hypothesized that repletion of Mg, which is chelated by citrate anticoagulant, could reduce platelet storage lesion severity when given in conjunction with storage at a refrigerated temperature.

METHODS:

Apheresis platelet units were collected from healthy donors and stored at 22°C or 4°C. On Days 0, 2, 4, and 8, samples were collected for analyses of receptor-mediated aggregation, coagulation, adhesion to collagen under flow, and viability. In the first series, samples were given anacute dose of MgSO4 before testing; in the second series, storage bags were supplemented with 0-, 3-, or 6-mM MgSO4.

RESULTS:

Acutely delivered MgSO4 induced a more rapid coagulation time in apheresis platelets, further enhanced by storage at 4°C. Plateletadhesion to a collagen surface while exposed to arterial shear rates (920 s) was enhanced by MgSO4 supplementation-acute MgSO4 had a large effect on adhesion of fresh platelets, which diminished more rapidly in 22°C samples, while storage with MgSO4 showed significant benefits even out to Day 4 at both temperatures. Although 4°C storage improves the longevity of platelet aggregation responses to agonists, MgSO4 supplementation did not change those responses.

CONCLUSION:

Acute MgSO4 reduces clot time likely through the transient increase of free Ca. Limited differences between platelet function inacute delivery of and storage with MgSO4 diminish the possibility that Mg-induced metabolic inhibition of platelets synergizes with 4°C storage. Regardless, magnesium supplementation to platelets is an exciting possibility in transfusion because the adhesion response of 22°C-stored platelets on Day 4 is significantly enhanced when stored with 6-mM MgSO4

| Tags : coagulopathie

01/11/2015

IED à pied: Amputations 2aires fréquentes

Outcomes after Long-Term Follow-Up of Combat-Related Extremity Injuries in a Multidisciplinary Limb Salvage Clinic

Casey K et Al. Ann Vasc Surg. 2015 Apr;29(3):496-501

Background: Although the incidence of casualties from the Global War on Terror is decreasing, there remains a focus on the long-term sequelae from injuries sustained in the combatPatients with prior significant limb injuries remain at risk of future complications. This study examines our institution’s experience with a multidisciplinary team approach toward this challenging patient population.

Methods: A retrospective review was performed on all patients treated in a single institution Limb Preservation Clinic over a 2-year period. Those patients who sustained a combatrelated injury in theater were examined. Patient demographics, mechanism of injury, amputation rates, time to amputation, and reasons for failure were examined.

Results: Ninety-four patients were evaluated in our multidisciplinary Limb Preservation Clinic over a 2-year period. Twenty patients (21%) were seen for combat-related injuries. Sixteen patients were evaluated and treated for chronic complications at a median of 13 months from their injury. All 16 patients were male with a median age of 24 years (range, 20e35). Ten patients sustained injuries secondary to a dismounted improvised explosive device (IED). All 16 patients had extensive soft tissue injuries and associated fractures. Only 2 patients sustained a vascular injury. The median number of prior surgeries to the affected limb was 8 (range, 3e19). The limb salvage rate of 37% was lower than our noncombat cohort (47%). The most common reasons for delayed amputation included chronic pain, osteomyelitis, and soft tissue infections.

Conclusions: The high secondary amputation rates seen in this cohort underscores the need for long-term follow-up. Despite successful initial outcomes, many patients eventually progress to limb loss. Patients who sustain a dismounted IED are at greatest risk for a delayed amputationIdentifying and addressing those factors which lead to delayed amputation should be a priority for returning war veterans and focus of future studies.

23/10/2015

Quelle place pour les facteurs de la coagulation ?

PlaceFactCoag.jpg

Clic sur l'image pour suivre la conférence

11/10/2015

Les blessés français en afghanistan

Epid Blessés Français.jpg

09/10/2015

Pas bon si TA < 100

Hypotension is 100 mm Hg on the battlefield

Eastridge DJ et All. Am J Surg. 2011 Oct;202(4):404-8

BACKGROUND:

Historically, emergency physicians and trauma surgeons have referred to a systolic blood pressure (SBP) of 90 mm Hg as hypotension. Recent evidence from the civilian trauma literature suggests that 110 mm Hg may be more appropriate based on associated acidosis and outcome measures. In this analysis, we sought to determine the relationship between SBP, hypoperfusion, and mortality in the combat casualty.

METHODS:

A total of 7,180 US military combat casualties from the Joint Theater Trauma Registry from 2002 to 2009 were analyzed with respect to admission SBP, base deficit, and mortality. Base deficit, as a measure of hypoperfusion, and mortality were plotted against 10-mm Hg increments in admission SBP.

RESULTS:

By plotting SBP, baseline mortality was less than 2% down to a level of 101 to 110 mm Hg, at which point the slope of the curve increased dramatically to a mortality rate of 45.1% in casualties with an SBP of 60 mm Hg or less but more than 0 mm Hg. A presenting SBP of 0 mm Hg was associated with 100% mortality. The data also established a similar effect for base deficit with a sharp increase in the rate of acidosis, which became manifest at an SBP in the range of 90 to 100 mm Hg.

Hypotension Is 100.jpg

CONCLUSIONS:

This analysis shows that an SBP of 100 mm Hg or less may be a better and more clinically relevant definition of hypotension and impending hypoperfusion in the combat casualty. One utility of this analysis may be the more expeditious identification of battlefield casualties in need of life-saving interventions such as the need for blood or surgical intervention.

 

 

 

 

20/09/2015

The Operational Patient Care Pathway

The Operational Patient Care Pathway

Une évolution importante de nos amis anglais qui précise le concept du "Prolonged Field Care" et révisent le concept de la golden Hour et des minutes de platine pour le 10-1-2 + 2

UK Battlefield.jpg

For debate: the Operational Patient Care Pathway

Bricknell M. J R Army Med Corps. 2014 Mar;160(1):64-9

| Tags : tactique

18/09/2015

Coagulopathie traumatique: Mécanismes

Trauma-Induced Coagulopathy: An Institution's 35 Year Perspective on Practice and Research

Gonzales E. et Al. Scandinavian Journal of Surgery 103: 89–103, 2014

TraumaCoag.jpg

| Tags : coagulopathie

01/08/2015

Milieu isolé: Mieux vaut avoir été préparé(e)

Preparing for Operations in a Resource-Depleted and/or Extended Evacuation Environment

Corey G et Al. J Spec Oper Med. 2013 Fall;13(3):74-80

The wars in Afghanistan and Iraq are the only conflicts to which many medics have ever been exposed. These mature theaters have robust medical systems that ensure rapid access to full-spectrum medical care for all combat-wounded and medically injured personnel. As current conflicts draw to a close, U.S. medics may be deployed to environments that will require the ability to stabilize casualties for longer than 1 hour. Historical mission analysis reveals the need to review skills that have not been emphasized during upgrade and predeployment training. This unit’s preparation for the extended care environment can be accomplished using a 4-point approach: (1) review of specific long-term skills training, (2) an extended care lab that reviews extended care skills and then lets the medic practice in a real-time scenario, (3) introduction to the HITMAN mnemonic tool, which helps identify and address patient needs, and (4) teleconsultation.

30/07/2015

ATLS: Référence en ballistique ? Bof !

Myths and Misinformation About Gunshot Wounds may Adversely Affect Proper Treatment.

Hafertepen SC et Al. World J Surg. 2015 Jul;39(7):1840-7

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La pertinence de l'ATLS est régulièrement battue en brèche pour les systèmes de prise en charge des traumatisés organisés en réseau. Historiquement il s'agissait d'apporter des connaissances de base à des équipes novices en la matière. Une revue cochrane n'est pas du tout en faveur. Un éditorial récent, mais il n'est pas isolé, exprime bien le caractère non adapté de ce concept à la réalité des trauma center actuels. Certains vont très loin dans la critique mettant en évidence dans le contenu même des dernières révisions la retranscription de données non validées. C'est le cas du document proposé. Au delà du caractère structurant réel d'un acronyme, c'est bien d'un contenu basique (trop) et souvent erroné dont nous devons être conscient.

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BACKGROUND:

Poorly designed experiments and popular media have led to multiple myths about wound ballistics. Some of these myths have been incorporated into the trauma literature as fact and are included in Advanced Trauma Life Support (ATLS). We hypothesized that these erroneous beliefs would be prevalent, even among those providing care for patients with gunshot wounds (GSWs), but could be addressed through education.

METHODS:

ATLS course content was reviewed. Several myths involving wound ballistics were identified. Clinically relevant myths were chosen including wounding mechanism, lead poisoning, debridement, and antibiotic use. Subsequently, surgery and emergency medicine services at three different trauma centers were studied. All three sites were busy, urban trauma centers with a significant amount of penetrating trauma. A pre-test was administered prior to a lecture on wound ballistics followed by a post-test. Pre- and post-test scores were compared and correlated with demographic data including ATLS course completion, firearm/ballistics experience, and years of post-graduate medical experience (PGME).

RESULTS:

One-hundred and fifteen clinicians participated in the study. A mean pre-test score of 34 % improved to 78 % on the post-test with associated improvements in all areas of knowledge (p < 0.001). Years of PGME correlated with higher pre-test score (p = 0.021); however, ATLSstatus did not (p = 0.774).

CONCLUSIONS:

Erroneous beliefs involving wound ballistics are prevalent even among clinicians who frequently treat victims of GSWs and could lead to inappropriate treatment. Focused education markedly improved knowledge. The ATLS course and manual promulgate some of these myths and should be revised.

 

20/07/2015

Echo en hélico: Avec formation solide !

Prospective evaluation of prehospital trauma ultrasound during aeromedical transport.

Press GM et Al. J Emerg Med. 2014 Dec;47(6):638-45

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L'apport de l'échographie est incontournable pour la prise en charge des traumatisés. Son emploi en prehospitalier est proposé. Pour autant la mise en oeuvre de ce moyen d'exploration n'est pas si simple et demande une grande expertise. Le travail présenté porte sur la mise en oeuvre de ce type d'exploration par technicinens paramédicaux expérimentés et ayant suivi une formation sur une période de deux mois. malgré cela leur performance reste modeste. Un examen négatif de permet pas de conclure. Ceci plaide pour un peu de modération concernant l'engouement actuel. Comme pour tout il faut investir sur la formation pour être performant.

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BACKGROUND:

Ultrasound is widely considered the initial diagnostic imaging modality for trauma. Preliminary studies have explored the use of trauma ultrasound in the prehospital setting, but the accuracy and potential utility is not well understood.

OBJECTIVE:

We sought to determine the accuracy of trauma ultrasound performed by helicopter emergency medical service (HEMS) providers.

METHODS:

Trauma ultrasound was performed in flight on adult patients during a 7-month period. Accuracy of the abdominal, cardiac, and lung components was determined by comparison to the presence of injury, primarily determined by computed tomography, and to required interventions.

RESULTS:

HEMS providers performed ultrasound on 293 patients during a 7-month period, completing 211 full extended Focused Assessment with Sonography for Trauma (EFAST) studies. HEMS providers interpreted 11% of studies as indeterminate. Sensitivity and specificity for hemoperitoneum was 46% (95% confidence interval [CI] 27.1%-94.1%) and 94.1% (95% CI 89.2%-97%), and for laparotomy 64.7% (95% CI 38.6%-84.7%) and 94% (95% CI 89.2%-96.8%), respectively. Sensitivity and specificity for pneumothorax were 18.7% (95% CI 8.9%-33.9%) and 99.5% (95% CI 98.2%-99.9%), and for thoracostomy were 50% (95% CI 22.3%-58.7%) and 99.8% (98.6%-100%), respectively. The positive likelihood ratio for laparotomy was 10.7 (95% CI 5.5-21) and for thoracostomy 235 (95% CI 31-1758), and the negative likelihood ratios were 0.4 (95% CI 0.2-0.7) and 0.5 (95% CI 0.3-0.8), respectively. Of 240 cardiac studies, there was one false-positive and three false-negative interpretations (none requiring intervention).

échographie

CONCLUSIONS:

HEMS providers performed EFAST with moderate accuracy. Specificity was high and positive interpretations raised the probability of injury requiring intervention. Negative interpretations were predictive, but sensitivity was not sufficient for ruling out injury.

| Tags : échographie

Dossier sauvetage au combat

 Dossier "Sauvetage au combat"

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| Tags : sauvetage

11/07/2015

ATLS: Une vision archaïque ?

ATLS: Archaic Trauma Life Support?

Wiles MD Anaesthesia 2015, 70, 893–906

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Un éditorial décoifffant mais pas tant que cela. Une revue cochrane récente ne trouvait pas d'argument en faveur de l'intérêt de l'ATLS (1). Le bien fondé de ce type de fromation est très débattue dans les pays disposant d'une structure spécialisée de prise en charge de traumatisé( 2). Peu étonnant quand on connait l'histoire de l'ATLS censé apporter des connaissances et une méthode à des personnels et des structures hospitalières non spécialisées en traumatologie. Les conclusions de cet éditorial repositionne très bien ce type de formations courtes

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No one could have imagined that when a light aircraft crashed in rural Nebraska in 1976, the nature of global trauma management would be forever altered. James Styner, an orthopaedic surgeon, was piloting the plane in question and the accident resulted in the death of his wife and serious injuries to himself and his four children. The standard of care that he and his family received in the local hospital in the aftermath of the crash so horrified Styner that he decided to establish a new system for the management of major trauma...........................

Archaic ATLS.jpg

......So what direction should trauma training take in the future?

I would suggest the following:

1 Treat ATLS as a ‘basic’ trauma course, with attendance limited to junior medical staff with no trauma experience. Candidates will learn the common language and vocabulary of trauma management, which will be of benefit when they subsequently attend trauma calls in clinical practice. In the developing world, where resources and personnel are  limited, ATLS will continue to have a role.

2 Stop routine recertification of ATLS for individuals experienced in trauma management. Given the high cost of these courses (~£600 (€825; $918) for certification and £350 (€482; $535) for recertification) this practice will account for a significant proportion of an individual’s annual study leave budget. This time and money would be better invested in developing enhanced leadership, communication and teamworking skills.

3 In line with the Royal College of Anaesthetists, remove ATLS certification as a prerequisite for the completion of training in surgery and emergency medicine. Instead, focus on ensuring adequate experience in the management of major trauma.

4 Similarly, for consultant posts that include trauma management, remove ATLS certification as an appointment criterion.

Evidence of experience in trauma management, alongside formal training in leadership and/or human factors, would be of greater relevance.

5 Require regular team-training sessions for MTC staff, either by video review or utilising simulation, ideally within the team’s usual working environment. This would allow training to be institution-specific, with the potential to refine protocols and undertake focused debriefs of recent cases.

When introduced almost 40 years ago, ATLS represented the cutting edge of trauma management; unfortunately, the course has failed to evolve at a pace that allows it to be relevant to the care delivered in modern MTCs. This course without doubt revolutionised trauma care, but it should now be reserved for use in isolated rural centres or environments where trauma is managed infrequently and with limited resources. The King is dead, long live the King.

03/07/2015

Fibrinogène avec le TXA ?: Plutôt oui

Association of Cryoprecipitate and Tranexamic Acid With Improved Survival Following Wartime Injury: Findings From the MATTERs II Study

Morrison JJ et Al. JAMA Surg. 2013;148(3):218-225.

 

Objective To quantify the impact of fibrinogen-containing cryoprecipitate in addition to the antifibrinolytic tranexamic acid on survival in combat injured.

Design Retrospective observational study comparing the mortality of 4 groups: tranexamic acid only, cryoprecipitate only, tranexamic acid and cryoprecipitate, and neither tranexamic acid nor cryoprecipitate. To balance comparisons, propensity scores were developed and added as covariates to logistic regression models predicting mortality.

Setting A Role 3 Combat Surgical Hospital in southern Afghanistan.

Patients A total of 1332 patients were identified from prospectively collected UK and US trauma registries who required 1 U or more of packed red blood cells and composed the following groups: tranexamic acid (n = 148), cryoprecipitate (n = 168), tranexamic acid/cryoprecipitate (n = 258), and no tranexamic acid/cryoprecipitate (n = 758).

Main Outcome Measure In-hospital mortality.

Results Injury Severity Scores were highest in the cryoprecipitate (mean [SD], 28.3 [15.7]) and tranexamic acid/cryoprecipitate (mean [SD], 26 [14.9]) groups compared with the tranexamic acid (mean [SD], 23.0 [19.2]) and no tranexamic acid/cryoprecipitate (mean [SD], 21.2 [18.5]) (P < .001) groups. Despite greater Injury Severity Scores and packed red blood cell requirements, mortality was lowest in the tranexamic acid/cryoprecipitate (11.6%) and tranexamic acid (18.2%) groups compared with the cryoprecipitate (21.4%) and no tranexamic acid/cryoprecipitate (23.6%) groups. Tranexamic acid and cryoprecipitate were independently associated with a similarly reduced mortality (odds ratio, 0.61; 95% CI, 0.42-0.89; P = .01 and odds ratio, 0.61; 95% CI, 0.40-0.94; P = .02, respectively). The combined tranexamic acid and cryoprecipitate effect vs neither in a synergy model had an odds ratio of 0.34 (95% CI, 0.20-0.58; P < .001), reflecting nonsignificant interaction (P = .21).

Conclusions Cryoprecipitate may independently add to the survival benefit of tranexamic acid in the seriously injured requiring transfusion. Additional study is necessary to define the role of fibrinogen in resuscitation from hemorrhagic shock.

 

| Tags : coagulopathie