Pre-hospital intra-osseous freeze dried plasma transfusion: a case report
Background: Hemorrhage and coagulopathy are among the leading causes of death in combat and are considered the leading causes of preventable deaths. Plasma, in the form of Fresh Frozen Plasma (FFP) is considered a key component in the Damage Control Resuscitation performed within hospitals. Freeze-Dried Plasma (FDP) can be stored at room temperature and therefore is potentially useful in pre-hospital conditions. Our case report join to few cases where FDP was administered at the point of injury. It is also unique as it describes an intra- osseous administration given to pediatric patient.
Case report: M.S. otherwise healthy 13 year old girl was injured due to gunshots and grenade blast. On the first triage by the IDF medical teams she suffered from: Severe hemorrhagic shock, (Blood pressure could not be measured, Heart rate 163), superficial wounds to her face, (forehead and Rt. Eye), gunshot wounds with active bleeding from her Lt. Arm and her RT. Knee (Mangled Extremity Severity Score (MESS) 8) and open fractures of left elbow and right thigh. A peripheral intravenous catheter was established and 1 g tranexamic acid in 500 ml of Hartman fluid were administered. Due to difficulties in establishing a functioning intra-venous line, an intra-osseous catheter was established and one unit of FDP (250 ml) was given in the field. She was transferred by a military medical team to a regional civilian hospital for further treatment. Upon arrival to the hospital her blood pressure and heart rate were significantly improved. After three weeks of hospitalization M.S. was discharged and she was returned to her homeland.
Conclusion: We have described the successful use of FDP for pre hospital resuscitation of a 13 year old girl suffering from severe hemorrhagic shock as a result of gunshots and grenade blast. This case report demonstrates that intra-osseous FDP administration for as part pre hospital resuscitation of children has a favorable outcome.
A Serious Adult Intraosseous Catheter Complication and Review of the Literature.
Current guidelines recommend the use of intraosseous access when IV access is not readily attainable. The pediatric literaturere ports an excellent safety profile, whereas only small prospective studies exist in the adult literature. We report a case of vasopressor extravasation and threatened limb perfusion related to intraosseous access use and our management of the complication. We further report our subsequent systematic review of intraosseous access in the adult population.
Ovid Medline was searched from 1946 to January 2015.
Articles pertaining to intraosseous access in the adult population (age greater than or equal to 14 years) were selected. Search terms were "infusion, intraosseous" (all subfields included), and intraosseous access" as key words.
One author conducted the initial literature review. All authors assessed the methodological quality of the studies and consensus was used to ensure studies met inclusion criteria.
The case of vasopressor extravasation was successfully treated with pharmacologic interventions, which reversed the effects of the extravasated vasopressors: intraosseous phentolamine, topical nitroglycerin ointment, and intraarterial verapamil and nitroglycerin. Our systematic review of the adult literature found 2,332 instances of intraosseous insertion. A total of 2,106 intraosseous insertion attempts were made into either the tibia or the humerus; 192 were unsuccessful, with an overall success rate of 91%. Five insertions were associated withserious complications. A total of 226 insertion attempts were made into the sternum; 54 were unsuccessful, with an overall success rate of 76%.
Color Doppler ultrasonography has been described as a method to verify placement of an intraosseous catheter. A high-frequency linear array transducer is placed near the intraosseous insertion site in either transverse or longitudinal axis. The color Doppler sample box is adjusted to include the subcutaneous compartment, the periosteum, and the intraosseous space, with the tomographic plane oriented to intersect the axis of the intraosseous needle . A 10-mL syringe filled with normal saline is attached to the intraosseous catheter and is rapidly infused with real-time ultrasonography imaging. If the intraosseous catheter is properly placed, color Doppler signal is seen in the subperiosteal (intraosseous) compartment. The presence of color Doppler signal in the extraosseous compartment indicates improper intraosseous catheter placement with extravasation.
Intraosseous catheter insertion provides a means for rapid delivery of medications to the vascular compartment with a favorable safety profile. Our systematic literature review of adult intraosseous access demonstrates an excellent safety profile with serious complications occurring in 0.3% of attempts. We report an event of vasopressor extravasation that was potentially limb threatening. Therapy included local treatment and injection of intraarterial vasodilators. Intraosseous access complications should continue to be reported, so that the medical community will be better equipped to treat them as they arise.
Saving the critically injured trauma patient: a retrospective analysis of 1000 uses of intraosseous access
Intraosseous access (IO) is becoming increasingly accepted in adult populations as an alternative to peripheral vascular access; however, there is still insufficient evidence in large patient groups supporting its use.
Retrospective review. This paper reports on the use of IO devices over a 7-year period from August 2006 to August 2013 during combat operations in Afghanistan. A database search of the Joint Theatre Trauma Registry (JTTR) was carried out looking for all the incidences of IO access use during this time. Excel (Microsoft) was used to manage the dataset and perform descriptive statistics on the patient demographics, injuries, treatments and complications that were retrieved.
1014 IO devices were used in 830 adult patients with no major complications. The rate of minor complications, the majority of which were device failure, was 1.38%. 5124 separate infusions of blood products or fluids occurred via IO access, with 36% being of packed red cells. On average, each casualty received 6.95 different infusions of blood products and fluids, and 3.28 separate infusions of drugs through IO access. 32 different drugs were infused to 367 patients via IO, the most frequent being anaesthetic agents. IO access was used in the prehospital environment, during tactical helicopter evacuation and within hospitals.
IO access can be used to administer a wide variety of life-saving medications quickly, easily and with low-complication rates. This highlights its valuable role as an alternative method of obtaining vascular access, vital when resuscitating the critically injured trauma patient.
Intraosseous infusion rates under high pressure: a cadaveric comparison of anatomic sites
Dans notre pratique le choix d'un abord tibial est le plus fréquent mais certainement pas le plus pertinent chez l'adulte. Le taux de succès de 1ère pose, le débit atteint les les aléas de perfusion font qu'un abord huméral ou sternal sont un meilleur choix. C'est ce laisse supposer ce document.
When traditional vascular access methods fail, emergency access through the intraosseous (IO) route can be lifesaving. Fluids, medications, and blood components have all been delivered through these devices. We sought to compare the performance of IO devices placed in the sternum, humeral head, and proximal tibia using a fresh human cadaver model.
Commercially available IO infusion devices were placed into fresh human cadavers: sternum (FAST-1), humeral head (EZ-IO), and proximal tibia (EZ-IO). Sequentially, the volume of 0.9% saline infused into each site under 300 mm Hg pressure over 5 minutes was measured. Rates of successful initial IO device placement and subjective observations related to the devices were also recorded.
For 16 cadavers over a 5-minute bolus infusion, the total volume of fluid infused at the three IO access sites was 469 (190) mL for the sternum, 286 (218) mL for the humerus, and 154 (94) mL for the tibia. Thus, the mean (SD) flow rate infused at each site was as follows: (1) sternum, 93.7 (37.9) mL/min; (2) humerus, 57.1 (43.5) mL/min; and (3) tibia, 30.7 (18.7) mL/min. The tibial site had the greatest number of insertion difficulties.
This is the first study comparing the rate of flow at the three most clinically used adult IO infusion sites in an adult human cadaver model. Our results showed that the sternal site for IO access provided the most consistent and highest flow rate compared with the humeral and tibial insertion sites. The average flow rate in the sternum was 1.6 times greater than in the humerus and 3.1 times greater than in the tibia.
On s'en doutait mais cela est objectivé: Le recours à la perfusion intraosseuse est responsable d'embolie graisseuse. La survenue d'une telle complication est moindre quand la procédure de flush ne dépasse pas 300mmHg et que le débit est lent. Dont acte au moins pour le flush.
The primary study objective was to delineate the procedural aspects of intraosseous (IO) infusions responsible for fatintravasation by testing the hypothesis that the fat content of effluent blood increases during IO infusions.
IO cannulas were inserted into the proximal tibiae of 35 anesthetized swine (Sus scrofa, 50.1 ± 3.5 kg) and intravasated fat was assessed using a lipophilic fluoroprobe (Nile red) and by vascular ultrasound imaging. Effluent blood bone marrow fat was assessed at baseline, during flush, and with regimens of controlled infusion pressures (73-300 mmHg) and infusion flow rates (0.3-3.0 mL per second). Fat intravasation was also assessed with IO infusions at different tibial cannulation sites and in the distal femur. In 7 animals, the lipid uptake of alveolar macrophages and lung tissue assessed for fat embolic burden using oil red O stain 24 hours post infusion. Additionally, bone marrow shear-strain was assessed radiographically with IO infusions.
Fat intravasation was observed during all IO infusion regimens, with subclinical pulmonary fat emboli persisting 24 hours post infusion. It was noted that initial flush was a significant factor in fat intravasation, low levels of intravasation occurred with infusions ≤300 mmHg, fat intravasationand bone marrow shear-strain increased with IO infusion rates, and intravasation was influenced by cannula insertion site. Ultrasound findings suggest that echogenic particles consistent with fat emboli are carried in fast and slow venous blood flow fields. Echo reflective densities were observed to rise to the nondependent endovascular margins and coalesce in accordance with Stoke's law. In addition, ultrasound findings suggested that intravasated bone marrow fat was thrombogenic.
Results suggest that in swine the intravasation of bone marrow fat is a common consequence of IO infusion procedures and that its magnitude is influenced by the site of cannulation and infusion forces. Although the efficacy and benefits of IO infusions for emergent care are well established, emergency care providers also should be cognizant that infusion procedures affect bone marrow fat intravasation.
Le BIG et Le FAST1 sont les dispositifs historiques d'accès intraosseux par impaction. Ils ont évolué. La nouvelle version du BIG est le NIO, celle du FAST1 est le FASTX. On rappelle que le BIG est en o dotation dans l'armée français et que différence fondamentale le BIG ne s'applique pas en sternal, alors qu'il s'agit du site de pose exclusif du FAST. On peut penser que ce dernier est moins polyvalent qu'un système permettant un abord huméral, tibial ou iliaque (lire la fiche mémento).
Equipment and strategies for emergency tracheal access in the adult patient
Un document qui passe en revue les équipements à mettre en oeuvre lors de sutuation de CICO (Can't intubate can't oxygneate)
The inability to maintain oxygenation by non-invasive means is one of the most pressing emergencies in anaesthesia and emergency care. To prevent hypoxic brain damage and death in a ‘cannot intubate, cannot oxygenate’ situation, emergency percutaneous airway access must be performed immediately. Even though this emergency is rare, every anaesthetist should be capable of performing an emergency percutaneous airway as the situation may arise unexpectedly. Clear knowledge of the anatomy and the insertion technique, and repeated skill training are essential to ensure completion of this procedure rapidly and successfully. Various techniques have been described for emergency oxygenation and several commercial emergency cricothyroidotomy sets are available. There is, however, no consensus on the best technique or device. As each has its limitations, it is recommended that all anaesthetists are skilled in more than one technique of emergency percutaneous airway. Avoiding delay in initiating rescue techniques is at least as important as choice of device in determining outcome
Intraosseous Vascular Access through the Anterior Mandible – A Cadaver Model Pilot Study
L'anesthésie intraosseuse est bien connue des chirurgiens dentistes. Pour autant s'agit il d'une voie potentielle d'abord vasculaire ? Peut être, sous réserve de respecter la zone de ponction et éviter le nerf dentaire inférieur.
Several insertion sites have been described for intraosseous puncture in cases of emergencies when a conventional vascular access cannot be established. This pilot study has been designed to evaluate the feasibility of the mandibular bone for the use of an intraosseous vascular access in a cadaver model.
17 dentistry and 16 medical students participating in a voluntary course received a short introduction into the method and subsequently used the battery powered EZ-IO system with a 15 mm cannula for a puncture of the anterior mandible in 33 cadavers. The time needed to perform each procedure was evaluated. India ink was injected into the accesses and during the anatomy course cadavers were dissected to retrace the success or failure of the puncture. Dental students needed 25.5±18.9(mean±standard deviation)s and medical students 33±20.4 s for the procedure (p=0.18). Floor of mouth extravasation occurred in both groups in 3 cases. Success rates were 82 and 75% (p=0.93).
Despite floor of mouth extravasation of injected fluid into a mandibular intraosseous access might severely complicate this procedure, the anterior mandible may be helpful as an alternative to other intraosseous and intravenous insertion sites when these are not available in medical emergencies.
The israeli defense force experience with intraosseous access
Nadler R.et All. Mil Med. 2014 Nov;179(11):1254-7
La réalisation d'un abord vasculaire peut faire appel à la voie intraosseuse. Trois dispositifs sont prévus par la procédure du sauvetage au combat: le trocard de mallarmé, le BIG et l'EZ_IO. Si les études expérimentales sont en faveur de cette pratique, la réalité ne semble pas suivre notamment pour le BIG. Relativement peu de dispositifs ont eu un emploi enregistré avec un taux de succès faible. Peut être un problème de stratégie d'emploi ?
Obtaining vascular access is of paramount importance in trauma care. When peripheral venous access is indicated but cannot be obtained, the intraosseous route represents an alternative. The Bone Injection Gun (BIG) is the device used for intraosseous access by the Israeli Defense Force (IDF). The purpose of this study is to assess the success rate of intraosseous access using this device.
The IDF Trauma Registry from 1999 to 2012 was searched for patients for whom at least 1 attempt at intraosseous access was made.
37 attempts at intraosseous access were identified in 30 patients. Overall success rate was 50%. No differences in success rates were identified between different care givers. Overall mortality was 87%.
The use of BIG in the IDF was associated with a low success rate at obtaining intraosseous access. Although inability to achieve peripheral venous access can be considered an indicator for poor prognosis, the high mortality rate for patients treated with BIG can also stand for the provider's low confidence in using this tool, making its usemaking its use a last resort. This study serves as an example to ongoing learning process that includes data collection, analysis, and improvement, constantly taking place in the IDF
Complication with Intraosseous Access: Scandinavian Users’ Experience
Pas si idyllique que cela
What is the evidence of utility for intraosseous blood transfusion in damage-control resuscitation ?
Harris M et all. J Trauma Acute Care Surg. 2013 Nov;75(5):904-6
« The scientific and clinical evidence for the use of IO access is voluminous, as evidenced by the Scientific Bibliography provided by VidaCare,6 one of the large manufacturers of IO devices, and available in any routine literature search. However direct scientific and/or clinical data to support the use of IO access for the purpose of blood transfusion in adult humans are very limited to anecdotal reports.
the absence of good evidence supporting the use of IO access for the very critical function of blood transfusion in DCR places existing recommendations for its use in question. This lack of evidence is compounded by the clinical experience of the lead author. Multiple attempts to use IO access for blood transfusion, both in the civilian adult emergency setting and in combat casualty care, have repeatedly been unsuccessful »
1. La densité osseuse dépend de l'âge
2. La porosité osseuse dépend de la densité osseuse
3. La perméabilité osseuse dépend de la porosité
« The bone mineral density increases with age up to a peak density occurring in the early 20s. The soldier population is aged right at the peak of bone density for all races and sex.
the viscosity of pRBCs used in DCR is estimated to be greater than 10 cP.12 Since pRBCs are 10+ times more viscous than crystalloid solutions, it will require at least 10+ times the pressure to obtain the same flow rate as crystalloid in IO infusion.
Based on the Darcy’s Law, the only parameter a medical practitioner has to adjust to increase flow rate in an IO system in DCR is pressure. Increases in pressure not only strain the connections in the infusion system itself but also increase shearing forces in the fluid. Shearing forces may cause hemolysis of the transfused blood, loss of oxygen carrying capacity, and consequent development of rhabdomyolysis
we postulate that maximum flow rates attainable for transfusion of blood products used in DCR via the IO route are simply inadequate for successful resuscitation »
La mise en place d'un abord intra-osseux peut faire appel à une aiguille de Jamshidi, le Bone Injection Gun ou BIG et l'EZ-IO. Le BIG est un dispositif à impaction dont l'efficacité est reconnue mais dont le maniement peut être délicat. La société PersysMedical propose une novelle version du BIG qui corrige certains défauts. La clavette de sécurité est remplacée par un dispositif de sécurité beaucoup plus pratique, il n'est pas possible d'initier la percussion tant que le dispositif n'est pas plaqué à 90° contre une surface plane. Enfin ce déclenchement nécessite une poussée important puis l'attraction du corps du dispositif évitant ainsi un déclenchement intempestif du système.
La voie humérale apparait ête l'alternative de choix à la voie tibiale
Proximal humerus intraosseous infusion: a preferred emergency venous access. PAxton et all. J Trauma. 2009 Sep;67(3):606-11.
Si la pose d'un cathéter intraosseux est associée à une douleur tolérable, ce n'est pas le cas de la perfusion de solutés par cette voie surtout si le blessé est conscient. La douleur est atténuée mais pas calmée par l'administration de bolus de lidocaïne (Au moins 40 mg soit 4 ml de lidocaïne à 1%), suivie d'une injection lente de 1à ml de sérum physiologique. Des bolus sont ensuite nécessaire. Il semble que la douleur soit proportionnelle à la pression d'injection. Il semblerait que le recours à la voie humérale soit associée à une douleur moindre.