Pour la coagulation: HEA de haut PM pas bon ?

Comparisons of lactated Ringer’s and Hextend resuscitation on hemodynamics and coagulation following femur injury and severe hemorrhage in pigs

Wenjun Z et all J Trauma Acute Care Surg. 2013;74: 732-740

After traumatic hemorrhage, coagulation function was restored within 6 hours with LR resuscitation but not with Hextend. The lack of recovery after Hextend is likely caused by greater hemodilution and possible effects of starches on coagulation substrates and further documents the need to restrict the use of high-molecular-weight starch in resuscitation fluids for bleeding casualties.

On rappelle que l'Hextend est un HEA 670/0.75 et que le voluven est un HEA 130/0,4 dont les effets sur la coagulation sont réputées étant moindres.