Salé 7,5%: Ne pas dépasser 500 ml

The effects of hypertonic saline solution (7.5%) on coagulation and fibrinolysis: an in vitro assessment using thromboelastography.

Tan TS et Al. Anaesthesia. 2002 Jul;57(7):644-8.

 

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Ce travail met en avant le caractère dose-dépendant des effets des solutions hypertoniques salines sur la coagulation. Elle confirme des travaux plus anciens (1) et milite au moins pour une utilisation raisonnée, limitée à  deux administrations. Ceci est cohérent avec la proposition faite par la procédure du sauvetage au combat.

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We studied the effects of hypertonic (7.5%) and normal saline on coagulation and fibrinolysis in an in vitro model using thromboelastography of human whole blood. Reaction times increased and alpha angles decreased with hypertonic saline replacement at 7.5% blood volume compared with similar dilution with normal saline.

At 10% blood volume replacement with hypertonic saline, reaction and coagulation times were significantly increased and alpha angles were decreased. Clot lysis at 30 min was also significantly reduced. We conclude that 7.5% hypertonic saline solution has anticoagulant effects if it replaces 7.5% or more of blood volume.