Hydrogel hémostatique: Cela arrive

The next frontier in hemorrhagic management: A comprehensive review on development of natural polymer-based injectable hydrogels as promising hemostatic dressings

Sanya A et Al. Chemical Engineering Journal  10.1016/j.cej.2024.155033

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L'idée d'injecter un produit hémostatique (poudre, petites épnges, gel) au contact d'une lésion qui saigne n'est pas nouvelle et de nombreux travaux de recherche sont en train  de paraître dans la littérature (1, 2). Cet article fait une courte synthèse des enjeux de ce type de produit qui paraissent bien complémentaire des moyens mécanique d'arrêt des hémorragies.

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Unmet needs in controlling uncontrolled hemorrhage in emergency, surgical, and battlefield scenarios have sparked widespread interest in developing new hemostatic technologies. Despite the availability of a wide range of commercially available hemostats, sealants, and adhesives, the development of ideal hemostatic formulations with remarkable properties such as the ability to promptly staunch bleeding under wet and dynamic conditions remains a challenge. Injectable polymeric hydrogels with superior hemostatic qualities besides their irregular wound filling capability, and minimal invasiveness have received considerable interest in recent years because of their attractive properties particularly useful in bleeding management. In this article, the most recent advances in the fabrication of injectable hydrogel systems from natural polymers towards hemostatic applications are discussed based on an extensive review of the literature. Additionally, the inherent hemostatic attributes of each polymer have been highlighted alongwith a comprehensive overview of various mechanisms through which injectable hydrogels achieve hemostasis. Furthermore, the challenges that need to be tackled towards accelerating the translation of these novel hemostatic hydrogel systems to clinical practice are emphasized and future directions for research in the field are also presented.

 

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