Hémostase: L'émergence des nanoparticules ?

Nano hemostat solution: immediate hemostasis at the nanoscale

Ellis-Behnke RG et all. Nanomedicine: Nanotechnology, Biology, and Medicine 2 (2006) 207 – 215

--------------------------------------------------------------------------------------

Hemostasis is a major problem in surgical procedures and after major trauma. There are few effective methods to stop bleeding without causing secondary damage. We used a self-assembling peptide that establishes a nanofiber barrier to achieve complete hemostasis immediately when applied directly to a wound in the brain, spinal cord, femoral artery, liver, or skin of mammals. This novel therapy stops bleeding without the use of pressure, cauterization, vasoconstriction, coagulation, or cross-linked adhesives. The self-assembling solution is nontoxic and nonimmunogenic, and the breakdown products are amino acids, which are tissue building blocks that can be used to repair the site of injury. Here we report the first use of nanotechnology to achieve complete hemostasis in less than 15 seconds, hich could fundamentally change how much blood is needed during surgery of the future.

--------------------------------------------------------------------------------------

Dans ce modèle une hémostase obtenue en moins de 15 secondes par un mécanisme peu évident:

1. ["First, we know that the hemostasis is not explainable by clotting. Blood clots are produced after injury, but do not begin to form until 1 to 2 minutes have elapsed, depending upon the status and coagulation history of the patient"]

2. ["the electron micrographs show no evidence of platelet aggregation at the interface of the material and wound site"]

3. ["We believe this tight contact is crucial to the hemostatic action because of the size of the self-assembling peptide units."]